Article

Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

2023-08-28

Abstract excerpt

The precision of gene editing technology is critical to creating safe and effective therapies for treating human disease. While the programmability of CRISPR-Cas systems has allowed for rapid innovation of new gene editing techniques, the off-target activity of these enzymes has hampered clinical development for novel therapeutics. Here we report the identification and characterization of a novel CRISPR-Cas12a enz...

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Literature Corpus work: 9c7e9dc2-7a13-5912-b05c-9682757fc0dc
DOI: 10.1101/2023.08.28.554880

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