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Virus-Like Particle Mediated CRISPR/Cas9 Delivery for Efficient and Safe Genome Editing

21 Dec 2020

Abstract excerpt

The discovery of designer nucleases has made genome editing much more efficient than before. The designer nucleases have been widely used for mechanistic studies, animal model generation and gene therapy development. However, potential off-targets and host immune responses are issues still need to be addressed for in vivo uses, especially clinical applications. Short term expression of the designer nucleases is...

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PMID: 33371215
DOI: 10.3390/life10120366

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