Article

Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1

2025-09-26

Abstract excerpt

GTP-binding protein 1 (GTPBP1) is a widespread translational GTPase closely related to elongation factor eEF1A. The loss of GTPBP1 leads to errors in neuronal development in animals and is associated with neurodegenerative disorders in humans. Although linked to translation and quality control mechanisms, GTPBP1 functions remain largely obscure. Similarly to eEF1A, GTPBP1 delivers cognate aminoacyl-tRNA to the rib...

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Literature Corpus work: 076b4080-1b84-52f0-bc39-70a797fa2f18
DOI: 10.1101/2025.09.26.678779

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