Article

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

2019-02-21

Abstract excerpt

The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1. Clinicopathological analyses revealed that phosphorylation of hTERT at threonine 249 occurs more frequently in advanced cancers. Using CRISPR/Cas9 genome editing, we intr...

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Literature Corpus work: 0cdde347-07c0-5190-88b5-48cef25bfded
DOI: 10.1101/556514

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