Article
CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.
PloS one - 1 Jan 2012
Marazita Mariela C, Ogara M Florencia, Sonzogni Silvina V, Martí Marcelo, Dusetti Nelson J, Pignataro Omar P, Cánepa Eduardo T
Abstract excerpt
DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4/6 inhibitors, has been reported to participate in the DNA damage response promoting DNA repair and cell survival. Here, we provide mechanistic insight into the activation mechanism of p19INK4d linked to the response to DNA damage. Results showed that p19INK4d becomes...
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