Article
CDK1 dependent phosphorylation of hTERT contributes to cancer progression.
Nature communications - 25 Mar 2020
Yasukawa Mami, Ando Yoshinari, Yamashita Taro, Matsuda Yoko, Shoji Shisako, Morioka Masaki Suimye, Kawaji Hideya, Shiozawa Kumiko, Machitani Mitsuhiro, Abe Takaya, Yamada Shinji, Kaneko Mika K, Kato Yukinari, Furuta Yasuhide, Kondo Tadashi, Shirouzu Mikako, Hayashizaki Yoshihide, Kaneko Shuichi, Masutomi Kenkichi
Abstract excerpt
The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1. Clinicopathological analyses reveal that phosphorylation of hTERT at threonine 249 occurs more frequently in aggressive cancers. Using CRISPR/Cas9 genome editing, we...
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