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Article

Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.

The Journal of biological chemistry - 8 Mar 2013

Jung Hae-Yun, Wang Xin, Jun Sohee, Park Jae-Il

Abstract excerpt

Telomerase maintains the telomere, a specialized chromosomal end structure that is essential for genomic stability and cell immortalization. Telomerase is not active in most somatic cells, but its reactivation is one of the hallmarks of cancer. In this study, we found that dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (Dyrk2) negatively regulates telomerase activity. Dyrk2 phosphorylates TERT...

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Source

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Identifiers

PMID: 23362280
DOI: 10.1074/jbc.M112.416792
PMCID: PMC3591633

Genes

TERT
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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