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Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice.

Stem cell reports - 10 Oct 2017

Shinohara Takashi, Kazuki Kanako, Ogonuki Narumi, Morimoto Hiroko, Matoba Shogo, Hiramatsu Kei, Honma Kazuhisa, Suzuki Teruhiko, Hara Takahiko, Ogura Atsuo, Oshimura Mitsuo, Kanatsu-Shinohara Mito, Kazuki Yasuhiro

Abstract excerpt

The introduction of megabase-sized large DNA fragments into the germline has been a difficult task. Although microcell-mediated chromosome transfer into mouse embryonic stem cells (ESCs) allows the production of transchromosomic mice, ESCs have unstable karyotypes and germline transmission is unreliable by chimera formation. As spermatogonial stem cells (SSCs) are the only stem cells in the germline, they...

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Identifiers

PMID: 28943251
DOI: 10.1016/j.stemcr.2017.08.012
PMCID: PMC5639258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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