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Article

Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline.

Genesis (New York, N.Y. : 2000) - 1 Jun 2016

Koentgen Frank, Lin Jiangwei, Katidou Markella, Chang Isabelle, Khan Mona, Watts Jacqui, Mombaerts Peter

Abstract excerpt

Gene targeting in embryonic stem (ES) cells remains best practice for introducing complex mutations into the mouse germline. One aspect in this multistep process that has not been streamlined with regard to the logistics and ethics of mouse breeding is the efficiency of germline transmission: the transmission of the ES cell-derived genome through the germline of chimeras to their offspring. A method whereby male...

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Identifiers

PMID: 27012318
DOI: 10.1002/dvg.22938
PMCID: PMC5084746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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