Article

Chromosome Transplantation: Opportunities and Limitations

2024-03-15

Abstract excerpt

There are thousands of rare genetic diseases that could be treated with classical gene therapy strategies such as the addition of the defective gene via viral or non-viral delivery or by direct gene editing. However, several genetic defects are too complex for these approaches. These “genomic mutations” include aneuploidies, intra and inter chromosomal rearrangements, large deletions, or inversion and copy number...

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Literature Corpus work: 13707e11-84fd-5ecd-a298-62eaadd9d91a
DOI: 10.20944/preprints202403.0880.v1

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