Article

Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones

2019-05-30

Abstract excerpt

Atonal homolog 8 (Atoh8) is a transcription factor of the basic helix-loop-helix (bHLH) protein family, which is expressed in the cartilaginous elements of endochondral bones. To analyze its function during chondrogenesis we deleted Atoh8 in mice using a chondrocyte- ( Atoh8 flox/flox ;Col2a1-Cre ) and a germline- ( Atoh8 flox/flox ;Prx1-Cre female ) specific Cre allele. In both strains, Atoh8 deletion leads...

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Literature Corpus work: 0cb8431c-5a14-5d1c-a59d-99988c8f947e
DOI: 10.1101/655555

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