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Article

PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy

6 Mar 2019

Abstract excerpt

During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy. Using multiple mouse genetics models, we demonstrate in vivo that HDAC4 is required for the effects of PTHrP on chondrocyte differentiation. We further...

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PMID: 30843886
DOI: 10.1172/jci.insight.97903

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