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Article

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.

The Journal of clinical investigation - 1 Jul 2005

Kobayashi Tatsuya, Soegiarto Desi W, Yang Yingzi, Lanske Beate, Schipani Ernestina, McMahon Andrew P, Kronenberg Henry M

Abstract excerpt

In the developing growth plate, periarticular chondrocytes proliferate, differentiate into columnar chondrocytes, and then further differentiate into postmitotic hypertrophic chondrocytes. Parathyroid hormone-related (PTH-related) protein (PTHrP), regulated by Indian hedgehog (Ihh), prevents premature hypertrophic differentiation, thereby maintaining the length of columns. Ihh regulates cartilage development...

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Share to Chondrocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

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Share to Parathyroid Hormone-Related Protein

Share to Receptor, Parathyroid Hormone, Type 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 15951842
DOI: 10.1172/JCI24397
PMCID: PMC1143590

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.PMID 15951842Read ↗

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Semantic proximity Read ↗

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.Semantic proximity Read ↗

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.Semantic proximity Read ↗

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.Semantic proximity Read ↗

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiationSemantic proximity Read ↗

The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.Semantic proximity Read ↗

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.Semantic proximity Read ↗

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor.Semantic proximity Read ↗

Insulin-like growth factor-I is essential for embryonic bone development.Semantic proximity Read ↗

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.Semantic proximity Read ↗

Smad4 is required for the normal organization of the cartilage growth plate.Semantic proximity Read ↗

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating <i>Ihh</i> transcriptionSemantic proximity Read ↗

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