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Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh

22 Dec 2011

Abstract excerpt

Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes. The relative contribution of Atf4 in chondrocytes and osteoblasts to the regulation of skeletal development and bone formation is poorly understood. Investigations of the Atf4(-/-);Col2a1-Atf4 mouse model, in which Atf4 is selectively overexpressed in chondrocytes in...

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PMID: 22190639
DOI: 10.1242/dev.069575

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Chondrocytic Atf4 regulates osteoblast differentiation and function via IhhPMID 22190639Read ↗

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