Article
Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor.
PloS one - 1 Jan 2011
Chen Jingchen, Dai Fangping, Balakrishnan-Renuka Ajeesh, Leese Florian, Schempp Werner, Schaller Felix, Hoffmann Michael M, Morosan-Puopolo Gabriela, Yusuf Faisal, Bisschoff Izak Johannes, Chankiewitz Verena, Xue Jinglun, Chen Jingzhong, Ying Kang, Brand-Saberi Beate
Abstract excerpt
ATOH8 is a bHLH domain transcription factor implicated in the development of the nervous system, kidney, pancreas, retina and muscle. In the present study, we collected sequence of ATOH8 orthologues from 18 vertebrate species and 24 invertebrate species. The reconstruction of ATOH8 phylogeny and sequence analysis showed that this gene underwent notable divergences during evolution. For those vertebrate species...
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