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Article

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

5 Jul 2017

Abstract excerpt

The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that protect plants, fungi and animals against invading pathogens including bacteria. However, in mammals reactive oxygen species production paradoxically promotes virus pathogenicity by mechanisms not yet...

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PMID: 28701733
DOI: 10.1038/s41467-017-00057-x

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