Article

A Pan-Cancer Analysis of Lesion-Level Treatment Response to Extend the ‘Seed and Soil’ Paradigm

2025-09-18

Abstract excerpt

<h4>Background</h4> The classical “seed and soil” hypothesis suggests that metastatic spread is shaped by tumor-intrinsic traits (“seeds”) and the organ-specific microenvironment (“soil”). We expand this concept to explain lesion-level therapeutic responses and phenotypic variability across metastatic cancers. <h4>Methods</h4> We analyzed 55,220 lesions from 6,087 patients enrolled in 20 clinical trials across s...

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Literature Corpus work: 0c8512f3-f923-55b0-aa63-f68d7a3950b3
DOI: 10.1101/2025.09.16.25335893

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