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Paget’s “Seed and Soil” Theory of Cancer Metastasis: An Idea Whose Time has Come

18 Oct 2018

Abstract excerpt

The concept that the pattern of metastatic spread of cancer is not random and that cancer cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven Paget published his "seed and soil" hypothesis. He proposed that the spread of tumor cells is governed by interaction and cooperation between the cancer cells (seed) and the host organ (soil). Extensive studies during the last several...

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PMID: 30339548
DOI: 10.1097/pap.0000000000000219

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