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Article

Spatiotemporal Heterogeneity across Metastases and Organ-Specific Response Informs Drug Efficacy and Patient Survival in Colorectal Cancer.

Cancer research - 1 May 2021

Zhou Jiawei, Li Quefeng, Cao Yanguang

Abstract excerpt

The sum of target lesions is routinely used to evaluate patient objective responses to treatment in the RECIST criteria, but it fails to address response heterogeneity across metastases. This study argues that spatiotemporal heterogeneity across metastases and organ-specific response is informative for drug efficacy and patient survival. We analyzed the longitudinal data of 11,404 metastatic lesions in 2,802...

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Identifiers

PMID: 33589516
DOI: 10.1158/0008-5472.CAN-20-3665
PMCID: PMC8137573

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