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Article

Reovirus nonstructural protein σ1s is required for establishment of viremia and systemic dissemination

6 Nov 2009

Abstract excerpt

Serotype-specific patterns of reovirus disease in the CNS of newborn mice segregate with the viral S1 gene segment, which encodes attachment protein sigma1 and nonstructural protein sigma1s. The importance of receptor recognition in target cell selection by reovirus implicates the sigma1 protein as the primary effector of disease outcome. However, the contribution of sigma1s to reovirus disease is unknown. To...

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PMID: 19897716
DOI: 10.1073/pnas.0907412106

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