Article
Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission.
PLoS pathogens - 1 Mar 2015
Doyle Joshua D, Stencel-Baerenwald Jennifer E, Copeland Courtney A, Rhoads Jillian P, Brown Judy J, Boyd Kelli L, Atkinson James B, Dermody Terence S
Abstract excerpt
Reovirus is a nonenveloped mammalian virus that provides a useful model system for studies of viral infections in the young. Following internalization into host cells, the outermost capsid of reovirus virions is removed by endosomal cathepsin proteases. Determinants of capsid disassembly kinetics reside in the viral σ3 protein. However, the contribution of capsid stability to reovirus-induced disease is unknown....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.