Article

Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains

2019-03-06

Abstract excerpt

<h4>ABSTRACT</h4> The Dearing strain of Mammalian orthoreovirus (T3D) is undergoing clinical trials as an oncolytic virotherapeutic agent. In this study, a comprehensive phenotypic and genetic comparison of T3D virus stocks from various laboratories and commercial sources revealed that T3D laboratory strains differ substantially in their oncolytic activities in vitro and in vivo . Superior replication of the mo...

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Literature Corpus work: 44393e21-2935-5b58-a83b-f896f07b7527
DOI: 10.1101/569301

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