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Article

A single-amino-acid polymorphism in reovirus protein μ2 determines repression of interferon signaling and modulates myocarditis.

Journal of virology - 1 Feb 2012

Irvin Susan C, Zurney Jennifer, Ooms Laura S, Chappell James D, Dermody Terence S, Sherry Barbara

Abstract excerpt

Myocarditis is indicated as the second leading cause of sudden death in young adults. Reovirus induces myocarditis in neonatal mice, providing a tractable model system for investigation of this important disease. Alpha/beta-interferon (IFN-α/β) treatment improves cardiac function and inhibits viral replication in patients with chronic myocarditis, and the host IFN-α/β response is a determinant of reovirus...

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Identifiers

PMID: 22156521
DOI: 10.1128/JVI.06236-11
PMCID: PMC3302381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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