Article

Development of Human iPSC-based Microphysiogical Models of Transthyretin Amyloid Cardiomyopathy

2026-06-10

Abstract excerpt

<title>Abstract</title> <p> Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a restrictive cardiac disease caused by the deposition of TTR in the heart. TTR is synthesized by hepatocytes and circulates as a homotetramer carrying complex for thyroxine and retinol. Mutations in TTR destabilize the tetramer promoting its dissociation into monomers that can enter the heart and aggregate into amyloid fibrils d...

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Literature Corpus work: a0a362ea-2f99-50d1-a9f4-ff08396be14f
DOI: 10.21203/rs.3.rs-9636540/v1

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