Characterization of the cardiac proteome of wild-type transthyretin amyloidosis cardiomyopathy

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Myocardial accumulation of the protein transthyretin (TTR) can result in amyloid TTR cardiomyopathy (ATTR-CM), a form of restrictive heart disease with limited therapies and still generally poor clinical outcomes. The mechanisms by which TTR fibril accumulation elicits cardiac toxicity at the protein level remain largely unknown. Accordingly, we performed untargeted proteo...

Topics

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• Amyloid Neuropathies, Familial
• Cardiomyopathies
• Disease Models, Animal
• Heart Failure
• Mice, Transgenic
• Myocytes, Cardiac
• Phenotype
• Prealbumin

Identifiers and source

Literature Corpus work

6dbe18c8-3257-54e6-b443-bb20e492d6ec

DOI

10.1101/2025.09.29.679210