Article

Genomic ascertainment of <i>PALB2</i> -related cancer predisposition

2026-04-04

Abstract excerpt

<h4>PURPOSE</h4> To evaluate cancer risk, age-specific penetrance, and mortality associated with heterozygous pathogenic or likely pathogenic (P/LP) germline PALB2 variants identified through genomic ascertainment and to assess modification by family history of cancer. <h4>PATIENTS AND METHODS</h4> We conducted a case-control study in two large population-based adult cohorts: the UK Biobank (n=469,580) and Gei...

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Literature Corpus work: 4179ff63-97f3-59e9-bd18-54323625ff9e
DOI: 10.64898/2026.04.03.26349984

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