Age-Specific Ovarian Cancer Risk Among Individuals With Pathogenic Variants in PALB2.

doi:10.1200/PO-26-00167

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Article

Age-Specific Ovarian Cancer Risk Among Individuals With Pathogenic Variants in PALB2.

JCO precision oncology - 1 Aug 2026

Takabatake Koki, Kubista Nicolas, Rosito Maria Sol, Zhang Yue, Gruber Stephen B, Idos Gregory, Parmigiani Giovanni, Braun Danielle

Abstract excerpt

PURPOSE: Pathogenic germline variants (PGVs) in PALB2 are well-established risk factors for breast cancer, but their association with ovarian cancer (OC) remains less characterized. This study estimates age-specific OC risk among PALB2 PGV carriers using a Bayesian segregation analysis approach. METHODS: Family history, including OC diagnoses, was collected from probands with PGVs in PALB2 from the Clinical...

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PMID: 42647764
DOI: 10.1200/PO-26-00167

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PALB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.