Article

Interdependent and separable functions of <i>C. elegans</i> MRN-C complex members couple formation and repair of meiotic DSBs

2017-11-04

Abstract excerpt

Faithful inheritance of genetic information through sexual reproduction relies on the formation of crossovers between homologous chromosomes during meiosis, which in turn relies on the formation and repair of numerous double-strand DNA breaks (DSBs). As DSBs pose a potential threat to the genome, mechanisms that ensure timely and error-free DSB repair are crucial for successful meiosis. Here we identify NBS-1, the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c64d22a8-8e25-5257-a913-16fbf8a055c2
DOI: 10.1101/214015

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interdependent and separable functions of <i>C. elegans</i> MRN-C complex members couple formation and repair of meiotic DSBsDOI 10.1101/214015Read

The BRCA1-BARD1 complex associates with the synaptonemal complex and pro-crossover factors and influences RAD-51 dynamics during <i>Caenorhabditis elegans</i> meiosisSemantic proximity Read

Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.Semantic proximity Read

BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during <i>C. elegans</i> meiosisSemantic proximity Read

Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates.Semantic proximity Read

PARG establishes a functional module with BRCA1-BARD1 that controls DNA repair pathway choice during gametogenesisSemantic proximity Read

Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization.Semantic proximity Read

C. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression.Semantic proximity Read

Identification of DSB-1, a protein required for initiation of meiotic recombination in Caenorhabditis elegans, illuminates a crossover assurance checkpoint.Semantic proximity Read

Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases.Semantic proximity Read

C. elegans BRC-1-BRD-1 functions at an early step of DSB processing and inhibits supernumerary crossovers during male meiosisSemantic proximity Read

Loss of Meiotic Double Strand Breaks Triggers Recruitment of Recombination-independent Pro-crossover Factors in <i>C. elegans</i> SpermatogenesisSemantic proximity Read

Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.Semantic proximity Read