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Article

BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.

EMBO reports - 1 Mar 2008

Adamo Adele, Montemauri Paolo, Silva Nicola, Ward Jordan D, Boulton Simon J, La Volpe Adriana

Abstract excerpt

The breast and ovarian cancer susceptibility protein BRCA1 is evolutionarily conserved and functions in DNA double-strand break (DSB) repair through homologous recombination, but its role in meiosis is poorly understood. By using genetic analysis, we investigated the role of the Caenorhabditis elegans BRCA1 orthologue (brc-1) during meiotic prophase. The null mutant in the brc-1 gene is viable, fertile and shows...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18219312
DOI: 10.1038/sj.embor.7401167
PMCID: PMC2267377

Genes

BRCA1
MSH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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