Article

Endophenotype Guided Genome-Wide Association Study to Enhance Genetic Risk Prediction of Primary Open-Angle Glaucoma in African Ancestry Populations

2025-10-07

Abstract excerpt

Primary open angle glaucoma (POAG) is the leading cause of irreversible blindness, with genetic predisposition playing a major role. While most genetic studies have focused on variants directly associated with POAG, loci influencing POAG diagnosis and progression, through intermediate traits also known as endophenotypes, remain underexplored. These endophenotypes, including intraocular pressure (IOP), cup to disc...

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Literature Corpus work: 0c2aa4d8-58c0-540c-be65-db9cc2fe5fed
DOI: 10.1101/2025.09.29.25336758

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