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Article

Decoding Primary Open-Angle Glaucoma: A Multi-Omics Approach to Identify Druggable Effector Genes.

Investigative ophthalmology & visual science - 1 Sept 2026

Guo Jingze, Yao Ying, Lin Hongliang, Niu Yongyi, Li Xue, Liu Jing, Liu Shunming, Qin Yongjie, Biradar Mahantesh, Shang Xianwen, Zhu Zhuoting, Plotnikov Denis, Wang Huan, Khawaja Anthony P, He Mingguang, Huang Yu, Zhang Hongyang

Abstract excerpt

Purpose: Genomewide association studies (GWAS) have identified numerous primary open angle glaucoma (POAG) risk loci, yet most reside in non-coding regions with unclear function. Mapping these loci to effector genes can elucidate disease mechanisms, identify functionally conserved variants, improve cross-ancestry risk prediction by reducing population-specific noise, and uncover shared therapeutic targets....

Read the complete abstract on PubMed

Topics

Humans
Glaucoma, Open-Angle
Genome-Wide Association Study
Quantitative Trait Loci
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Multiomics

Genetic Risk Score

Source

Open in PubMed Open full text

Identifiers

PMID: 42725910
DOI: 10.1167/iovs.67.11.19
PMCID: PMC13577014

Provenance

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