Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The path to open-angle glaucoma gene discovery: endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness.

Investigative ophthalmology & visual science - 1 Jul 2010

Charlesworth Jac, Kramer Patricia L, Dyer Tom, Diego Victor, Samples John R, Craig Jamie E, Mackey David A, Hewitt Alex W, Blangero John, Wirtz Mary K

Abstract excerpt

PURPOSE. Primary open-angle glaucoma (POAG) is a complex disease with a genetic architecture that can be simplified through the investigation of individual traits underlying disease risk. It has been well studied in twin models, and this study was undertaken to investigate the heritability of som...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve Fibers
Share to Cornea
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glaucoma, Open-Angle

Share to Intraocular Pressure

Share to Optic Disk

Share to Retinal Ganglion Cells

Share to Tonometry, Ocular

Source

Open in PubMed Open full text

Identifiers

PMID: 20237253
DOI: 10.1167/iovs.09-4786
PMCID: PMC2904007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20237253-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The path to open-angle glaucoma gene discovery: endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness.PMID 20237253Read ↗

Endophenotype Guided Genome-Wide Association Study to Enhance Genetic Risk Prediction of Primary Open-Angle Glaucoma in African Ancestry PopulationsSemantic proximity Read ↗

Genomic structural equation Modeling analysis of glaucoma Endophenotypes: investigating genetic architecture and non-intraocular pressure mechanisms.Semantic proximity Read ↗

Genetic architecture of open angle glaucoma and related determinants.Semantic proximity Read ↗

An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.Semantic proximity Read ↗

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis.Semantic proximity Read ↗

Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks.Semantic proximity Read ↗

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.Semantic proximity Read ↗

Glaucoma Heritability: Molecular Mechanisms of Disease.Semantic proximity Read ↗

Predictive Power of Polygenic Risk Scores for Intraocular Pressure or Vertical Cup-Disc Ratio.Semantic proximity Read ↗

The Cell and Molecular Biology of Complex Forms of Glaucoma: Updates on Genetic, Environmental, and Epigenetic Risk FactorsSemantic proximity Read ↗

Multi-trait Polygenic Probability Risk Score Enhances Glaucoma Prediction Across AncestriesSemantic proximity Read ↗

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.