Article

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s disease

2020-02-03

Abstract excerpt

We conducted a large multi-ethnic meta-analysis of genome-wide association studies for primary open-angle glaucoma (POAG) on a total of 34,179 cases vs 349,321 controls, and identified 127 independent risk loci, almost doubling the number of known loci for POAG. The majority of loci have broadly consistent effect across European, Asian and African ancestries. We identify a link, both genome-wide and at specific lo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63a63f7a-aaf6-5f19-844b-e1d76cff67aa
DOI: 10.1101/2020.01.30.927822

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s diseaseDOI 10.1101/2020.01.30.927822Read

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.Semantic proximity Read

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.Semantic proximity Read

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.Semantic proximity Read

Genetic Factors Implicated in the Investigation of Possible Connections between Alzheimer’s Disease and Primary Open Angle GlaucomaSemantic proximity Read

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.Semantic proximity Read

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.Semantic proximity Read

The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology.Semantic proximity Read

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.Semantic proximity Read

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.Semantic proximity Read

Primary open angle glaucoma genetics: The common variants and their clinical associations (Review).Semantic proximity Read

Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferationSemantic proximity Read

Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degenerationSemantic proximity Read