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Immortalizing Mesenchymal Stromal Cells from Aged Donors While Keeping Their Essential Features

16 Jun 2020

Abstract excerpt

Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral regenerative medicine approaches or to study age-related diseases, such as osteoarthiritis (OA). MSCs can be transduced with immortalizing genes to overcome this limitation, but transduction of primary...

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PMID: 32612662
DOI: 10.1155/2020/5726947

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