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Article

Novel Immortal Cell Lines Support Cellular Heterogeneity in the Human Annulus Fibrosus

21 Jan 2016

Abstract excerpt

INTRODUCTION: Loss of annulus fibrosus (AF) integrity predisposes to disc herniation and is associated with IVD degeneration. Successful implementation of biomedical intervention therapy requires in-depth knowledge of IVD cell biology. We recently generated unique clonal human nucleus pulposus (NP) cell lines. Recurring functional cellular phenotypes from independent donors provided pivotal evidence for cell...

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PMID: 26794306
DOI: 10.1371/journal.pone.0144497

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