Article

Hemochromatosis Neural Archetype Reveals Iron Disruption in Motor Circuits

2022-10-24

Abstract excerpt

Our understanding of brain iron regulation and its disruption in disease is currently lacking. We previously found that motor circuitry is susceptible to the cumulative neurotoxic effects of excessive iron, leading to the manifestation of Parkinson’s disease. However, beyond a few well-known genes involved in peripheral iron metabolism, the underlying molecular mechanisms regulating central iron levels remain uncl...

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Literature Corpus work: 0c04d2db-47b9-59f9-a420-f0eec61b19d0
DOI: 10.1101/2022.10.22.22281386

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