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Article

Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders.

JAMA neurology - 1 Sept 2022

Loughnan Robert, Ahern Jonathan, Tompkins Cherisse, Palmer Clare E, Iversen John, Thompson Wesley K, Andreassen Ole, Jernigan Terry, Sugrue Leo, Dale Anders, Boyle Mary E T, Fan Chun Chieh

Abstract excerpt

Importance: Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder that leads to iron overload. Conflicting results from previous research has led some to believe the brain is spared the toxic effects of iron in HH. Objective: To test the association of the strongest genetic risk variant for HH on brainwide measures sensitive to iron deposition and the rates of movement disorders in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35913729
DOI: 10.1001/jamaneurol.2022.2030
PMCID: PMC9344392

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