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Article

Alzheimer's disease: A matter of blood-brain barrier dysfunction?

The Journal of experimental medicine - 6 Nov 2017

Montagne Axel, Zhao Zhen, Zlokovic Berislav V

Abstract excerpt

The blood-brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in Alzheimer's disease (AD) before dementia, neurodegeneration and/or brain atrophy occur. However, the role of BBB breakdown in neurodegenerative disorders is still not fully understood. Here, we examine BBB breakdown in animal models...

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Identifiers

PMID: 29061693
DOI: 10.1084/jem.20171406
PMCID: PMC5679168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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