Article
Targeting mutant p53-expressing tumours with a T cell receptor-like antibody specific for a wild-type antigen.
Nature communications - 26 Nov 2019
Low Lionel, Goh Angeline, Koh Joanna, Lim Samantha, Wang Cheng-I
Abstract excerpt
Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompatibility complex (MHC). Elevated levels of such p53-derived peptide-MHCs on tumour cells potentially differentiate...
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