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Article

Interaction of mutant p53 with p73: a Surface Plasmon Resonance and Atomic Force Spectroscopy study.

Biochimica et biophysica acta - 1 Jun 2014

Santini Simona, Di Agostino Silvia, Coppari Emilia, Bizzarri Anna Rita, Blandino Giovanni, Cannistraro Salvatore

Abstract excerpt

BACKGROUND: TP53 tumor suppressor gene is mutated in more than 50% of human tumors. Mutated p53 proteins could sequestrate and inactivate p73 reducing the apoptotic and anti-proliferative effects of the transcription factor, and yielding cancer cells more aggressive and chemoresistant. The possibility of using drugs to prevent the mutant p53/p73 complex formation preserving the p73 function, calls for a deeper...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24576672
DOI: 10.1016/j.bbagen.2014.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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