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Article

Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer.

Nuclear medicine communications - 1 Apr 2026

Oroujeni Maryam, Selvaraju Ram Kumar, Persson Helena, Dahllund Leif, Frejd Fredrik Y, Mortensen Anja C L

Abstract excerpt

OBJECTIVE: Development of companion diagnostics for targeted radionuclide therapy is critical, especially for full-size antibodies with prolonged circulation times. Engineering antibodies to modify their in-vivo pharmacokinetics, such as incorporating neonatal Fc receptor (FcRn)-binding mutations, can potentially enable earlier imaging timing and improved patient stratification. This study aimed to evaluate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Hyaluronan Receptors

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Share to Tomography, Emission-Computed, Single-Photon

Source

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Identifiers

PMID: 41496609
DOI: 10.1097/MNM.0000000000002100
PMCID: PMC12955976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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