Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.

doi:10.1016/j.celrep.2017.11.112

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Article

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.

Cell reports - 2 Jan 2018

Hwang Le-Ann, Phang Beng Hooi, Liew Oi Wah, Iqbal Jabed, Koh Xiao Hui, Koh Xin Yu, Othman Rashidah, Xue Yuezhen, Richards A Mark, Lane David P, Sabapathy Kanaga

Abstract excerpt

The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to generate such reagents: monoclonal antibodies against the most common R175H, R248Q, and R273H hotspot mutants of the tumor suppressor p53. These antibodies recognize their...

Topics

Animals
Antibodies, Monoclonal, Murine-Derived
Antibody Specificity
Female
Humans
Mice
Mice, Inbred BALB C
Mutation
Precision Medicine
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 29298430
DOI: 10.1016/j.celrep.2017.11.112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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