Article
The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2015
Chen Liang, Rashid Farooq, Shah Abdullah, Awan Hassaan M, Wu Mingming, Liu An, Wang Jun, Zhu Tao, Luo Zhaofeng, Shan Ge
Abstract excerpt
p53, known as a tumor suppressor, is a DNA binding protein that regulates cell cycle, activates DNA repair proteins, and triggers apoptosis in multicellular animals. More than 50% of human cancers contain a mutation or deletion of the p53 gene, and p53R175 is one of the hot spots of p53 mutation. Nucleic acid aptamers are short single-stranded oligonucleotides that are able to bind various targets, and they are...
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