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Article

Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts.

Oncotarget - 24 Jan 2017

Liu Xujie, Dong Chengyan, Shi Jiyun, Ma Teng, Jin Zhongxia, Jia Bing, Liu Zhaofei, Shen Li, Wang Fan

Abstract excerpt

Epidermal growth factor receptor mutant III (EGFRvIII) is exclusively expressed in tumors, such as glioblastoma, breast cancer and hepatocellular carcinoma, but never in normal organs. Increasing evidence suggests that EGFRvIII has clinical significance in glioblastoma prognosis due to its enhanced tumorigenicity and chemo/radio resistance, thus the development of an imaging approach to early detect EGFRvIII...

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Identifiers

PMID: 28031526
DOI: 10.18632/oncotarget.14088
PMCID: PMC5351638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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