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Article

Immune signaling mediates stromal changes to support epithelial reprogramming in celiac duodenum

21 Jul 2025

Abstract excerpt

Celiac disease is a chronic autoimmune disorder affecting 0.5%-1% of the population. Here, we assembled the most comprehensive single-cell RNA sequencing (scRNA-seq) dataset in celiac disease (CeD) to date, including 203,555 cells across 21 active CeD and 11 control duodenal samples. CeD was characterized by single-cell differential changes in abundance, gene expression, and cell-cell interactions across cellular...

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PMID: 40694474
DOI: 10.1016/j.celrep.2025.116039

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