Article

Mammalian CST averts replication failure by preventing G-quadruplex accumulation

2018-06-22

Abstract excerpt

Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres and genome-wide. We previously showed that CST binds and disrupts G-quadruplex (G4) DNA in vitro , suggesting that CST may prevent in vivo blocks to replication by resolving G4 structures. Here, we demonstrate that CST binds and unfolds G4 with similar efficienc...

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Literature Corpus work: 8eaf9eec-650e-52f8-a173-5874e5bf481f
DOI: 10.1101/354050

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