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Human CST abundance determines recovery from diverse forms of DNA damage and replication stress

29 Oct 2014

Abstract excerpt

Mammalian CST (CTC1-STN1-TEN1) is a telomere-associated complex that functions in telomere duplex replication and fill-in synthesis of the telomeric C-strand following telomerase action. CST also facilitates genome-wide replication recovery after HU-induced fork stalling by increasing origin firing. CTC1 and STN1 were originally isolated as a DNA polymerase α stimulatory factor. Here we explore how CST abundance...

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Identifiers

PMID: 25483097
DOI: 10.4161/15384101.2014.964100

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