Back to search

Article

Pan-active imidazolopiperazine antimalarials target the <i>Plasmodium falciparum</i> intracellular secretory pathway

2019-08-15

Abstract excerpt

<h4> A bstract </h4> One of the most promising new compound classes in clinical development for the treatment of malaria is the imidazolopiperazines (IZPs) class. Human trials have demonstrated that members of the IZP series, which includes KAF156 (Ganaplacide) and GNF179, are potent and effective against Plasmodium symptomatic asexual blood-stage infections. Unlike other commonly used antimalarials, they also...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
db971877-5839-5a4e-8b98-2c3c548852ac
DOI
10.1101/735894
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Pan-active imidazolopiperazine antimalarials target the <i>Plasmodium falciparum</i> intracellular secretory pathwayDOI 10.1101/735894
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathwaySemantic proximity
A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in <i>P. falciparum</i> MalariaSemantic proximity
Characterization of apicomplexan amino acid transporters (ApiATs) in the malaria parasite <i>Plasmodium falciparum</i>Semantic proximity
MMV687794 blocks <i>Plasmodium falciparum</i> invasion of red blood cells by targeting a Surface-associated Lipid-Interacting Rhoptry Protein, <i>Pf</i> SLIRPSemantic proximity
A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria.Semantic proximity
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of <i>Plasmodium</i>Semantic proximity
Mammalian deubiquitinating enzyme inhibitors display <i>in vitro</i> and <i>in vivo</i> activity against malaria parasites and potentiate artemisinin actionSemantic proximity
Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease <i>Pf</i> ROM8 and cation channel <i>Pf</i> CSC1Semantic proximity
Cellular and molecular basis of <i>Pf</i> Coronin function in artemisinin resistance in <i>Plasmodium falciparum</i>Semantic proximity
The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in <i>P. falciparum</i> parasitesSemantic proximity
Peroxide antimalarial drugs target redox homeostasis in <i>Plasmodium falciparum</i> infected red blood cellsSemantic proximity
<i>Plasmodium falciparum</i> diacylglycerol acyltransferase maintains phospholipid homeostasis to regulate sexual differentiation, ER stress, and cytoadhesionSemantic proximity
Select a neighboring publication to make it the new centre.