Article

A druggable oxidative folding pathway in the endoplasmic reticulum of human malaria parasites

2020-05-15

Abstract excerpt

Malaria remains a major global health problem, and there exists a constant need to identify druggable weaknesses in P. falciparum biology. The endoplasmic reticulum (ER) has many essential roles in the asexual lifecycle and may offer new drug targets, but it remains critically understudied. We generated conditional mutants of the putative redox-active, ER chaperone Pf J2, and show that it is essential for parasi...

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Literature Corpus work: f7bcfa47-0143-52ae-ae6a-e4c3fba89018
DOI: 10.1101/2020.05.13.093591

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