Article

Polypharmacology is an enduring and nearly universal property of kinase inhibitors

2026-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Despite decades of research, current understanding of the spectrum of targets bound by kinase inhibitors remains incomplete. This complicates mechanism of action studies, drug repurposing, and development of new therapies. Here, we describe kinome-wide profiling of an optimal kinase library (OKL) comprising 192 small molecules selected based on stage of clinical development, chemical diversity,...

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Literature Corpus work: 2c95fecf-9674-53b6-a56e-83eee7d1466e
DOI: 10.64898/2026.03.17.711623

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